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KMID : 1134820000290020288
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 2 p.288 ~ p.293
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Effect of Crude Saponin Fraction from Korean Red Ginseng on Physiological Events of Ovariectomized Rat
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Kwak Yi-Seong
Wee Jae-Joon
Hwang Seok-Yeon
Kyung Jong-Su
Kim Si-Kwan
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Abstract
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This study was carried out to investigate the effect of crude saponin fraction from Korean red ginseng on physiological events of ovariectomized rats. The saponin fraction was prepared by Diaion HP-20 adsorption chromatography and spirit. Total of 50 rats were divided into 5 groups : normal control (NC), sham-ovariectomized (SO), ovariectomized (OR), ovariectomized and saponin treated (OS), and normal control treated with saponin (NS). Saponin was intraperitonally administered for 8 weeks. Ovariectomy was carried out at 1st and 2nd week of experiment. Right-side ovary of rat was removed at 1st week, the other was done at 2nd week. The body weights of ovariectomized rats showed no significant changes but that of NS group showed significant increase (p<0.05) compared with NC group. Ovariectomy of rats reduced the weights of femur by 6 to 8% compared with that of NC group. In addition, femur weight of NS group was 5 to 6% higher than that of NC. Uterus weight showed no significant differences by saponin treatment or ovariectomy. Serum testosterone level of ovariectomized rats increased by 60 times compared with that of NC. However, administration of crude saponin to ovariectomized rat attenuated testosterone level to almost that of NC. These results suggest that Korean red ginseng saponin attenuates physiological disorders induced by malfunction of ovary.
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KEYWORD
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crude saponin fraction, red ginseng, rat, ovariectomy, physiological function
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